15 Best Books on DNA Structure To Read in [2022]

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All macromolecules are important. However, DNA is the very cause of existence of life on earth. The Golden period of DNA double-helix structure discovery is cherished forever. You could buy such a moment on your scientific career too.

To get assisted on your DNA molecular structure based scientific research, you must take a glimpse on these books. These are the 15 Best Books on DNA structure to be read before and while performing experiments on DNA molecules.


Best Books on DNA for Every Structural Researcher

Not all books are meant to be read. But make sure that the ones you pick are the best available to you. Here is a list of 15 Best books on DNA structure. Some are good but some are brilliant. These are best among the best to be read by all the molecular and computational biologists.


1. Understanding DNA: The Molecule and How it Works

Understanding DNA: The Molecule and How It Works is a book that has been composed by a group of four authors named Chris R Calladine, Horace Drew, Ben Luisi, and Andrew Travers.

Every scientific community is aware of the impact DNA causes on the existence of life on earth. This book is a brief overview of the functional, structural, and molecular aspects of DNA and the genetic codes it carries.

The book includes a detailed description of the different types of structures that DNA can exist in. It also mentions the role of DNA in biological processes.

Why You Should Buy This Book

  • It explains the step-by-step phenomenon of biological processes such as DNA replication, transcription, and so on
  • The text is clear, precise, with a great style of writing. Indispensable reading for all the biochemists, molecular biologists, and geneticists
  • A fundamental book for people switching from non-biological backgrounds into biology, and want to understand the mechanism of DNA functionalities

Level (best suitable for): Beginner to Intermediate


2. DNA Structure and Function

DNA Structure and Function by Richard R Sindon, is a complete volume for comprehensive studies on the biological structure of DNA and functions.

It consist latest data on Z-DNA, triplex DNA, and other DNA conformations. Description on chromosomal organizations, DNA-Protein interactions and biological effects of structure.

Separate boxes with key experiments and ideas are written precisely within boxes. More than 150 diagrams and figures are illustrated to give the visual impact of experimental concepts

The book is divided into different sections and each section is brief and descriptive.

The chapters include the historical narrative along with the current and latest innovations and biological relevance studied in DNA conformations.

Why You Should Buy This Book

  • An ideal book for undergraduates and graduates who seek to study the nucleic acids, specifically DNA of different forms and types
  • The language is simple, and the text is easy to understand. Relevant and high-resolution diagrams and structures are present for elucidated understanding
  • The book is an amalgamation of fields such as genetics, molecular biology, biochemistry, and so on.
  • Understanding the mechanism of DNA structures and the functions it performs
  • Recommended for every core biology scientist

Level (best suitable for): Beginner to Intermediate


3. DNA Science: A First Course

DNA Science: A First Course, authored by David Micklos and Greg A Freyer, is a highly acclaimed textbook for studying the DNA molecules.

The book incorporates a state-of-the-art collection of severely tested and reliable experiments in the molecular biology field developed at the International and renowned Dolan DNA Learning Center of the Cold Spring Harbor Laboratory, which is known for the construction and cloning of recombinant DNA molecules.

These studies are more than a decade old experiment proven by the teaching and research communities in advance biology programs.

The book is a part of the general biology, microbiology, cell biology, molecular genetics, introductory biology, and structural biology curriculum.

The data of the entire human genome sequence is introduced along with the impact on medical research and evolution fields.

Why You Should Buy This Book

  • This volume can be classified into different sections. The first 8 chapters are updated and include the latest information.
  • Each experiment has a background theory that explains how to plan the experiment.
  • The book is highly descriptive with tremendous narration and includes precise protocols for laboratory experiments.
  • The laboratory techniques and gene isolation analysis are reliable protocols derived after 10 years of research and development.
  • The flowcharts make the protocols easy to understand.
  • The materials required reagents, precautions, and tips for good results are also mentioned in a stepwise manner for optimum results in DNA experiments.

Level (best suitable for): Intermediate to Advance


4. The Double Helix

The double helix: A Personal Account of the discovery of the structure of DNA, authored by James Watson, is a personal account of Watson and Crick’s famous, Nobel prize-winning discovery of the double-helical structure of DNA.

Francis Crick and James Watson brought a revolutionary change in the world of biochemistry by discovering this structure of DNA, which is the molecule of life and coding.

Watson and Crick were very young when they discovered it, and this book is a legendary tale of the hardships and struggle of ambitious scientists.

The book includes the rivalry of the two, with Linus Pauling to identify the building block of life.

Why You Should Buy This Book

  • The book is a personal account, and hence it can inspire young minds to seek pleasure in solving the great mysteries of science.
  • The language is simple, and the text is clear to understand
  • The narration follows a good course
  • Recommended for every reader, especially the biological historians and molecular biologists, desperate for a breakthrough discovery

Level (best suitable for): Beginner to Intermediate


5. DNA Structure and Recognition

DNA Structure and Recognition by Stephen Neidle, is a short, concise comprehensive study on DNA structure from tip to toe.

The book includes the first principles after this discovery of DNA structure, followed by the study of drugs and protein interaction with DNA molecules.

This book will guide researchers to understand the essential need to study in areas of gene regulation and DNA and target drug action.

Why You Should Buy This Book

  • The book is short and small
  • The language is simple to understand and intriguing
  • Brief and precise notes on relevant topics
  • Nicely organized sections for specific topics
  • Handbook for quick reference while performing experiments
  • Recommended to molecular biologists and geneticists working in the research field related to drug action

Level (best suitable for): Intermediate to Advance


6. DNA Topology

DNA Topology authored by Andrew bates and Anthony Maxwell is a brief overview of the genetic material of most of the life forms that is DNA.

DNA has gained all the attention soon after the discovery of the double helix structure by Watson and Crick. With time, the importance of DNA in biological processes has become clear and vivid.

The book includes one of the most relevant topics related to the DNA that is the topological configuration such as supercoiling, catenation, knotting, and many more.

The DNA structure can be fully understood when the basics of DNA are in full grasp of advanced research. This book focuses on simple ideas and also emphasizes on the wide functionalities of DNA topology.

Why You Should Buy This Book

  • The textbook is comprehensive and easy to understand by the readers
  • This includes an important and overlooked topic that is the topological configuration
  • DNA can be fully understood when the topology is clear, and this book serves that purpose
  • Quick reference for core laboratory researchers
  • Recommended for every molecular biologist, geneticist, and biochemists

Level (best suitable for): Intermediate to Advance


7. Nucleic Acids in Chemistry and Biology

Nucleic acids in chemistry and biology is edited by a group of more than ten people. This chapter includes information on the structure, function, and reactions of nucleic acids.

The book is center around molecular biology and understanding of crucial topics of complex biological processes.

The core of the book is about the biological and chemical nature of nucleic acids. It also discusses the intermediate product RNA in the central dogma.

The book has been written by scientific experts with brilliant teaching experience for years. It includes information on chemical reactions, protein, and DNA interactions, and drug interactions.

There is a brief history of the discovery of nucleic acids followed by the molecular structure and functions of DNA and RNA.

Why You Should Buy This Book

  • The highlight chapters are devoted to the synthesis of nucleosides, nucleotides, oligonucleotides, and their analogs, and techniques applied for the analysis of nucleic acids.
  • The content is supported by a reliable list of references from validated resources.
  • The topics are represented in an integrated manner.
  • The text is easy and clear to understand.
  • Every graduate and undergraduate student belonging to the field of chemistry, biochemistry, molecular biology, genetics, and biotechnology can rely on this book for understanding the basic biochemical nature of nucleic acids.

Level (best suitable for): Beginner to Intermediate


8. Rosalind Franklin: The Dark Lady of DNA

Rosalind Franklin: The Dark Lady of DNA authored by Brenda Maddox, is a biography of renowned scientist Rosalind Franklin. Brenda Maddox is a multiple award winner biographer who has written several biographies for various famous people of the world. One such book that has revealed the brilliant personality of Rosalind Franklin is this one.

Franklin was the scientist based on whose ideas Watson and Crick discovered the breakthrough double helix DNA structure that won them the Nobel Prize. It was the data and photographs of DNA by Rosalind Franklin’s work that form the basis of such an enormous discovery.

The story of Franklin has been told powerfully. Franklin was an ambitious, single-minded, intelligent woman, who, at a very young age, discovered the bases of DNA structure, however, she could not win the credits for her contribution and couldn’t propose the DNA structure model also.

Why You Should Buy This Book

  • Every woman with a scientific approach must read this book to draw inspiration
  • This story has been written intriguingly so that readers can enjoy a good narration
  • The language has been kept simple and easy to read by all the readers across the earth
  • It exemplifies the life of a simple woman that led to the discovery of the wonderful DNA structure

Level (best suitable for): Beginner to Intermediate

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9. iGenetics: A Molecular Approach

iGenetics: A Molecular Approach, authored by Peter Russell, is a brief overview of genomics and its impact on molecular mechanisms.

It includes the latest and successful experimental methodologies of studying genes.

The chapters are divided briefly into different sections, the initial chapters include the molecular topics, and the chapters, later on, are more about sequences.

Why You Should Buy This Book

  • The text is organized and clear for understanding the topic briefly
  • There are key questions at the beginning of the chapter and keynotes are placed for extra information.
  • The book comes along with references to the websites that help the students to visualize the concepts illustrated in the text and understand the process in a better way
  • An advanced book with the latest technological information
  • Highly recommended for students beginning to learn molecular biology and genetics

Level (best suitable for): Intermediate to Advance


10. The $1,000 Genome

The $1000 Genome, the revolution in DNA sequencing, and the new era of personalized medicine penned down by Kevin Davies is a book that provides insight on the application of the Human Genome Project in 2003.

Since the completion of the Human Genome Project, there has been a constant urge to sequence the individual genetic code in a thousand dollars.

In this book, Kevin Davies had predicted that by 2011 it would be feasible to sequence the entire genome in a thousand dollars but presently the cost is even less than $1000.

The author has also included important and trending topics such as personalized and genomic medicine. He has beautifully presented advanced information, which is now a reality.

Why You Should Buy This Book

  • The book is a compilation of extraordinary possibilities. It has taught many researchers in the past, and the teachings are quite true.
  • It has helped the pharmaceutical companies that have created many life-saving drugs for individuals based on their specific genome.
  • The book also emphasizes the problem of incurable diseases such as Parkinson’s.
  • Highly recommended for bioinformaticians and computational biologist to learn the principles of human genome sequencing
  • To learn to devise the methods of human genome sequencing at a more feasible price

Level (best suitable for): Intermediate to Advance


11. DNA Nanotechnology: From Structure to Function

DNA Nanotechnology from structure to function edited by Chunhai Fan focuses on the importance of DNA nanotechnology and the potential applications in core biology.

The book is broadly divided into three sections. The first section is a brief introduction about DNA nanotechnology, the elements associated with the Nanotechnology, and provides basic information on DNA technology.

The second part of the book is about the static and dynamic features of DNA nanotechnology. This section describes the design and working of static and dynamic elements of Nanostructures. The development of Nanodevices, DNA origami, DNA walkers, have been covered in section two.

The final and third part of the book is surrounded by applications of DNA technology. It includes topics such as computation drug delivery, biosensors, nanopore technologies, etc.

Why You Should Buy This Book

  • The book is promising with a comprehensive way of writing and broad discussion on the impact of nanotechnology in biological and medical sciences.
  • The book is ideal for graduate and Ph.D. research fellows, educators, lecturers, and professors to expand their knowledge base on this advanced technology of DNA studies.

Level (best suitable for): Intermediate to Advance


12. Mathematics of DNA Structure, Function and Interactions

Mathematics of DNA structure function and interactions has been edited by a group of five editors from all over the World.

With the success of the methods in DNA sequencing of human and other related genomes and understanding of molecular and cellular biology, the excitement has increased.

Mathematics has played a key role in discovering various positive results in the field of physics, chemistry, and biology.

This book of mathematics of DNA is unique due to its name and secondly due to the treasure of content it offers.

The volume is however dedicated to the renowned personality Nicholas Cozzarelli, for dedicating his life into fostering research and training between mathematics and molecular biology.

Why You Should Buy This Book

  • It includes 15 research papers, a personal remembrance of the scientist, and an overview of the latest mathematical approaches to solve the biological problems.
  • Advanced book for scientists with a mathematical background and little learning of DNA
  • Rich content with understandable language
  • Recommended for core biology and mathematics researches

Level (best suitable for): Intermediate to Advance


13. A Century of DNA

A Century of DNA history of the discovery of the structure and function of the genetic substance authored by Franklin Portugal and Jack Cohen.

It is a very basic book that revolves around research associated with the DNA molecule and the function it performs within the cell.

The book tries to answer the questions of the origin of DNA, its history, interrelated subjects of biophysics histology, biochemistry genetics organic chemistry and embryology, and many more.

The chapter is segmented into various sections. There is a chronological flow of information beginning from the development of ideas and principles on DNA followed by the protocols that led to the discovery of DNA.

The later sections include the discovery of genetic codes and the process of transcription and translation.

Why You Should Buy This Book

  • Basic book for a beginner learner
  • The text is intriguing with an engaging flow of content
  • This includes simple words and easy language
  • Must read by every biologist before learning DNA in depth.

Level (best suitable for): Beginner to Intermediate


14. Junk DNA: A Journey Through the Dark Matter of the Genome

Junk DNA: A Journey through the dark matter of the genome, author by Nessa Carey, is as interesting to read as the title of the book.

Not all the DNA is important for the regulation of genes and the production of proteins. Almost 98% of the human genome is of no use and serves no specific purpose. Hence, these regions of non-coding DNA are called junk sequences.

Most of the scientific world has paid attention to the coding part, its functions, and vital roles in cellular regulations. But junk DNA has also led to adding different research and treatment approaches which has even treated some of the anomalies/diseases.

DNA can play a significant role in the control of gene expression by switching off and on individual genes in entire genomes and chromosomes. These functions have encouraged scientists to redefine the meaning of gene

Why You Should Buy This Book

  • For extra text readers, this book is recommended
  • It provides additional information on secret regions of DNA
  • Junk DNA can provide a wide scope for medical biology research if one understands it well
  • Recommended for molecular biologists and geneticist

Level (best suitable for): Beginner


15. The Eighth Day of Creation

The eighth day of creation makers of the revolution in biology, authored by Horace Freeland Judson, is a wholesome book on the story of the origin and development of molecular biology in developed countries like the US, UK, and France.

The book describes the victory period when the double helix structure of DNA was discovered and the genetic codes were understood.

The book is highly acclaimed and considered to be the best history book in recent biological science

The book includes writings on historical scientific figures such as Rosalind Franklin. It also includes the development of molecular biology in these recent phases of DNA biotechnology

Why You Should Buy This Book

  • Must read by the biological historians
  • Easy to understand language and simple text
  • The flow of the text is engaging and informative too
  • Young minds can seek inspiration from renowned scientific figures of history

Level (best suitable for): Beginner to Intermediate

This wonderful list is an amalgamation of Best Books on DNA Structure. It includes basic books on DNA structure and its different forms. Some books are the laboratory manuals and technical guides to support the research. Few books are the memoirs and biographies of the renowned personalities in this domain.

Understanding DNA is not as difficult as it appears. All these books are highly recommended to every biologists and interdisciplinary field students. People belonging to physics, math, and chemistry can grasp the concepts through this book too.

DNA structure and its cellular mechanisms within cells has immense scope of research. You must read to know more about it.

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