15 Best Books on Genomics

It might come as a surprise to you, but huge bodies of humans and the small-sized bacteria share the same fundamentals of existence. The basic unit of life is the cell and it is composed of a nucleus. The nucleus is the master for governing lives since it contains the dynamic macromolecular structures called DNA/RNA.

Genomics is the most reputed and widely studied science field across the world. It has brought some revolutionary changes to the lifestyle of several organisms including human beings. The field has served immensely in healthcare, diagnostics, and therapeutics.

If you belong to the field of biology, particularly genomics, you have a bright career in the future with immense opportunities.

All that you need as a researcher are good books on genomics for guidance. You must fulfill the current requirement of advance computational skills integrated with biology. For that, you need these 15 best books on genomics.

 

Best Books on Genomics for General Information & Laboratory Guidance

Here is a list of the 15 best books that can shape the future of your career. These are the remarkable genomic books with authentic information from reliable sources.

We have gathered a quick list for you to choose from. Out of these 15 best books on genomics, here is the list of must-read and highly recommended books on different sub-areas of genomics.

If you’re a beginner and wish to understand the concepts and fundamentals underlying genomics then you can read these books- Introduction to Genomics and Bioinformatics and Functional Genomics

Intermediate to advanced level learners we would recommend these books- Concepts in Bioinformatics and Genomics and Genomics and Personalized Medicine

If you are an advanced learner with computational skills and interest, then you must go with these books on genomics with computation- A Crack in Creation, Genome Editing and Engineering and The Handbook of Statistical Genomics

Go through the description of each one of them to analyze your requirements.

 

1. Introduction to Genomics

Introduction to Genomics by Arthur Lesk is a compelling and updated textbook for studying genomics.

Overall, the book is a comparison between the evolutionary mechanism of different organisms, the construction of genomes, and its method of operation, the current state of study, and the future perspective of genomics.

The textbook is divided into 13 simple and concise chapters. The initial chapters are about the human genome project in detail. The chapters further include the latest bioinformatical methods of mapping, sequencing, and annotating and storing information in databases.

The description of the genomic pattern of prokaryotes, eukaryotes, and viruses is included in the midsections of the book. A comparative analysis of organisms at different hierarchy has been done.

Further, genomics and its effects on human health and diseases are discussed along with the important topics of anthropology.

The concluding chapters include the latest interdisciplinary field of science- transcriptomics, proteomics, metabolomics, and systems biology.

Why You Should Buy This Book

  • Each chapter is designed exclusively in a way to extend imaginative skills to the readers
  • Web-based problems are available at the end of every chapter to gain practice with the tools
  • Hints and answers are available along with the exercises to support self-learning
  • Highly illustrative figures allow visualization of complex structures
  • Recommended for beginners trying to understand genomics, belonging to the field of bioinformatics, genomics, and molecular biology

Level (best suitable for): Beginner to Intermediate

 

2. Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics is a specialized collection of genomics information and bioinformatical tools for genomic analysis. There is a total of 3 sections that include 21 chapters in the book.

The initial part of the book is on the analysis of DNA, RNA, and protein sequences. It includes a brief introduction to different sequence types. The chapter begins with accessing the sequence data from databases.

Performing specific analysis such as pairwise sequence alignment, multiple sequence alignment, using the Basic Local Alignment Search Tool, advanced database searching, and molecular phylogeny and evolution are some of the topics covered in the first part.

The second part of the book is the pirate genome-wide analysis of DNA, RNA, and protein. The DNA of eukaryotic chromosomes has been included in chapter 8. The brief of next-generation sequence data analysis and bioinformatics approaches for RNA analysis are included here.

The gene expression through microarray and RNA data is covered in chapter 11. Chapters 12, 13, and 14 are about protein analysis, structure analysis, proteomics, and functional genomics.

Section 3 is dedicated entirely to genome analysis. It begins with the discussion on genomes across the tree of life followed by genomes present in viruses, bacteria, and archaebacteria. The chapters further include details on the genomes of fungi, parasites, primates, etc.

The human genome and human diseases are mentioned in the concluding chapters of the book.

Why You Should Buy This Book

  • Simple text and easy language for understanding the concepts
  • Next-generation sequencing chapters and similar analysis chapters are written very well
  • Effective organization of chapters for easy navigation
  • Special focus on computational methods of analysis
  • Use of programming languages, NCBI utilities, command-line tools for performing analysis jobs
  • Recommended for bioinformaticians, molecular biologists, and geneticists

Level (best suitable for): Beginner to Intermediate

 

3. Introduction to Protein Science

Introduction to Protein Science is a dynamic compilation of the contemporary study of proteins. The book has been received very positively by proteomics, researchers, and students. Broadly the book is classified into a total of 9 chapters.

The first chapter is a brief introduction to the concept of proteins, what it is actually, and how it impacts the lives so much. The second chapter is about the dynamic structure of a protein such as the primary structure, secondary structure, tertiary structure, and finally the quaternary structure.

Just the next chapter is about the determination of protein structure. It includes the methods and protocols for the prediction of protein structure at different stages.

The fourth chapter is about the computational approach to understanding the protein sequence and structure. It includes details on the latest advanced bioinformatical software and tools to be used for the purpose.

Chapter 5 is more about the functional aspects of proteins. Proteins can behave as a catalyst that is as enzymes for carrying out several biochemical reactions. The chapter emphasizes enzyme structure, kinetics, and mechanism.

The evolutionary history of protein structure and function has been included in further chapters. Protein folding is a topic always up for discussion, hence a chapter has been dedicated to understanding the folding and design of proteins. The final chapter deals with the subjects of proteomics and systems biology.

Why You Should Buy This Book

  • This includes a brief introduction and rich information on protein functions and structure
  • Experimental techniques and methods for studying proteins in depth is included
  • Simple text and clear sections for a good reading experience
  • Active learning by students through exercises problems and Weblems at the end of each chapter
  • The ability to think proactively is imported to the students
  • The relevance between protein study and its application in the real world

Level (best suitable for): Intermediate to Advance

 

4. Concepts in Bioinformatics and Genomics

Concepts in Bioinformatics and Genomics are an extensive collection of mathematics, biology, and computer science. The book has been divided into different clear chapters.

The first chapter is a review of molecular biology that includes basic terminologies related to the subject. This chapter gives a rough idea to the non-biological students about the biological concepts to be used later.

Information organization and sequence databases are included in chapter 2. Molecular evolution is discussed in chapter three. Chapter 4 is a little mathematical with a topic such as substitution matrices.

Chapter 5 discusses pairwise sequence alignment followed by a chapter on basic local alignment sequence tools and multiple sequence alignment. Chapter 7 is about protein structure prediction. It is followed by Phylogenetics, genomics, transcript, and protein expression analysis. This marks the end of chapter 10.

The mathematical topic of basic probability is included in chapter 11. Chapter 12 is on the advanced probability for bioinformatics applications. It is followed by the programming basics and applications to bioinformatics. The concluding chapter 14 is about the mechanism of developing a bioinformatics tool.

Why You Should Buy This Book

  • The book is balanced and includes equal proportions of math and biology
  • The organization of chapters is fully flexible
  • A brief overview of molecular biology with essential vocabulary are provided at the very beginning
  • Mathematics chapters on probability and E-value
  • Basic chapters of computer programming
  • Case study of TP53 molecule in detail
  • Rich pedagogy

Level (best suitable for): Intermediate to Advance

 

5. Genomics and Personalized Medicine

Genomics and Personalized Medicine is a practical guide to an essential subject of genomics. The book is sectioned into a total of 22 brief chapters. It begins with an introductory chapter on the overview of the book.

Chapter 1 is a detailed account of personalized medicine and the factors that impact human health. Chapter 2 includes the fundamentals of the genome such as DNA, the difference in the genome from one person to another, the difference in the genome of men and women, and genome decoding.

The following chapter is a brief introduction to cancer genetics. It includes the causes of cancer and the genes responsible for causing cancer. Treatment of cancer through genetic information which is another interesting topic included in chapter 3.

Chapter 4 deals with genomics and cancer treatment. It throws light on the genome, sequencing of the cancer genome, sequencing in advanced cancer treatment, anticancer drugs, immunotherapy, and many more.

Interesting topics like solving mystery diseases, complex genetic diseases, pharmacogenomics, genomics for a healthy person, prenatal testing, effects of the environment on genome and epigenetics, transcriptomics, proteomics, personal microbiome, immune system and infectious diseases, aging and effect of aging on health, health devices, big data, and medicine, are all included as separate chapters in details.

The last 4 to 5 chapters are based on ethics, education, privacy, and cost for personalized medicines. The chapter ends on the future perspectives of personalized medicines and the technologies prevalent in these fields.

Why You Should Buy This Book

  • A highly accessible and practical guide
  • Written in clear and concise language
  • Simple words and lucid paragraphs
  • Separate sections for different topics in detail
  • Practical insight on how to access and make use of technologies and services currently available, such as for cancer treatment
  • This format is in a question-answer pattern for easy navigation
  • This includes authoritative resources on genomics and personalized medicines
  • Provides essential information for healthcare and genomics field of study

Level (best suitable for): Intermediate to Advance

 

6. A Crack in Creation

A Crack in Creation is an interesting book just as it has an interesting name.

It is briefly divided into two parts where the first part is the detailed account of the history of regularly interspaced short palindromic repeats system of bacterial immunity that is started in Spain a few years ago.

The second part is about the discovery of the modification system in the genomes of plants, animals, insects, etc.

The initial chapters of the book are only about the discovery and description of CRISPR. It includes the repair and replacement of mutant genes in higher organisms, particularly in treating human diseases. Special emphasis is given to gene therapy.

Several other methods of editing the DNA sequences are developed. The book talks about the great possibilities of these gene-editing technologies.

The final section of the book is about genome editing in various parts of the world. People who wish to study genome editing, especially based on the CRISPR method, should read this book at least once in detail.

Why You Should Buy This Book

  • The book is recommended for anyone interested in the future of basic biological research.
  • A journey through the past, present, and future on the most significant biological discoveries
  • A brief account on the history and present advanced technologies in gene modifications
  • This includes detail on the CRISPR system
  • Simplified text with the use of easy language
  • The comprehensive flow of chapters for easy navigation
  • Persuasive writing skills with authentic information

Level (best suitable for): Advanced

 

7. Genomics in the Cloud

Genomics in the Cloud is a compilation of basic and fundamental genomics along with computational technology. The book is divided into a total of 14 chapters. The first chapter is an introduction to the challenges and promises of big data in biology and life sciences, infrastructural challenges, and a cloud-based ecosystem for data sharing and analysis.

Chapter 2 is a brief account of genomics, Central dogma, DNA mutations, challenges of genomic scale, genomic variation, throughput sequencing, data generation, data processing and analysis, baby ant calling, data quality, and many more.

Details on computing technologies based on life sciences are included in chapter 3. Basic infrastructure components and performance bottlenecks are included. Types of processor, hardware-level of organization, and parallel computing is discussed in detail.

Chapter 3 concludes on pipelining for parallelization and automation. It also includes virtualization and cloud. Chapter 4 is a brief introduction to using cloud computing. Topics such as running basic commands in Google cloud shell, setting up custom VM, configuring IGV to read data from GCS buckets.

Chapter 5 deals with GATK, best practices for germ-line short variant discovery, and somatic variation discovery. Chapter 8 is about analysis executions with workflows, GATK workflow, and scatter-gather parallelism.

The further chapters are about deciphering real genomics workflows, running single workflows at scale with pipelines API, running many would close conveniently with Terra, interactive analysis in Jupyter notebook, assembling space in Terra, and more.

The concluding chapter is on making it a fully reproducible paper. It includes an overview of the case studies, generating a synthetic data set as a stand-in for the private data, recreating the data processing and analysis methodology.

Why You Should Buy This Book

  • A great compilation of genomics and computing technology background
  • This includes basic cloud computing operations
  • Learn interactive analysis using Jupyter notebook
  • Use Terra for securing collaboration and computational reproducibility
  • Scaling of workflow running in the cloud
  • Parallelization and cost optimization
  • GATK based practice pipelines
  • An easy and comprehensive book for cloud computing students with basics of genomics

Level (best suitable for): Intermediate to Advance

 

8. Genome: The Autobiography of A Species

Genome: The Autobiography of A Species is a remarkable book written by Matt Ridley. The author has beautifully explained the human species and the 23 chromosomes in 23 chapters. The book is unique since it has been written differently from other conventional genomics books.

The author has picked one newly discovered gene from every pair of chromosomes and written a descriptive account on each one of them. This way, each chapter with a new gene from a single pair of chromosomes accounts for a total of 23 chapters.

The book includes a brief description of human ancestry, history, and the future. Separate chapters are dedicated to human genetic diseases such as Huntington disease and Cancer. Separate chapters are dedicated to Gene therapy and eugenics.

The last/ending section of the book is about ethics and morals arising due to mapping genome sequences.

Why You Should Buy This Book

  • The book is written in a comprehensive style with clear cut chapters on every chromosome
  • Use of simple and easy language
  • A lucid and engaging guide to understanding double-helical DNA behind human existence
  • The book is eloquent and up-to-date
  • Highly recommended for molecular biologists, geneticists, biotechnologist, and bioinformatics belonging to intermediate level

Level (best suitable for): Beginner to Intermediate

 

9. Handbook of Statistical Genomics

The Handbook of Statistical Genomics is a compilation of ideas, analysis methods, algorithms, and historical literature associated with genomics. The book has been divided into a total of two volumes, each consisting of 18 chapters.

Chapter 1 is about the statistical modeling and inference in genetics followed by a chapter on linkage disequilibrium, recombination, and haplotype structure.  The topics such as- Mathematical models in population Genetics, coalescent theory, phylogeny estimation, and multi-species coalescent are discussed in further chapters.

The population structure, population genomic analysis, public genetics models for the study of protein evolution, adaptive molecular evolution, detecting natural selection, evolutionary quantitative genetics, conservation genetics, statistical methods for plant breeding, and forensic science are written in huge details as separate chapters.

The volume 2 is mostly based on the ethical issues in statistical genetics, descent-based mapping in pedigrees and populations, genome-wide association studies, replication and meta-analysis of genome-wide association studies, and inferences.

The causal relationships between risk factors and outcomes using a genetic variation, improving genetic association analysis through integration of function and notations of the human genome, variant interpretation and genomic medicine, prediction of phenotype from DNA variants, modeling gene expression, dynamics with Gaussian process inference, and many more similar topics are in volume 2.

The book is concluded on DNA methylation, statistical and computational methods in microbiome and metagenomics, and bacterial population genomics.

Why You Should Buy This Book

  • The book is very descriptive and a guide on statistical methods of genomics
  • Easy to understand, since simple words and language is used
  • Improving the practical skills of a student
  • Giving high order thinking skills to researchers
  • Lucid style of writing and separate sections for each topic
  • Recommended for biostatistician, Bioinformaticians, and genomics study students

Level (best suitable for): Advanced

 

10. Essential Genetics and Genomics

Essential Genetics and Genomics written by Daniel Hartl is a collective guide on modern Genetics and genomics. It includes essential topics related to genetics in a very precise way.

The book is divided into 15 clear cut chapters. The book begins with the general information on genes, genomes, and genetic code. It is followed by the studies of Mendel and transmission genetics. Chapter 3 is about the chromosomal basis of heredity.

Gene linkage, genetic mapping, human chromosome, and behavior are included in chapters 4 and 5. The next chapter is a detailed description of the structure of DNA, the process of replication, and the possible manipulations that could be done on genes.

After this, the Genetics of bacteria and their viruses is included as a separate chapter. Chapter 8 deals with the molecular Genetics of gene expression. It is followed by a chapter on the molecular mechanism of gene regulation.

Genomics, proteomics, and genetic engineering, genetic control of development, the molecular mechanism of mutation and DNA repair, the molecular Genetics of the cell cycle, and cancer, the genetic basis of complex traits are the concluding chapters of the book.

Why You Should Buy This Book

  • The book provides a comprehensive review of the basics of human Genetics
  • It includes recent problems and their possible solutions to enforce higher-order thinking skills in students
  • High-resolution images and pictures
  • Tables and supplementary information is provided

Level (best suitable for): Beginner to Intermediate

 

11. Public Health Genomics: The Essentials

Public Health Genomics: The Essentials compilation of the education of genomics in the area of public health. The book has been divided into three major parts. Part 1 includes 7 chapters with specific themes. Chapter 1 is brief in the past, present, and future of public health genomics. Chapter 2 is about the role of government in genomics.

The third chapter is a brief on the basics of molecular Genetics such as DNA replication, transcription, and translation gene expression mutations and polymorphism. Chapters 4 and 5 are based on population Genetics, race, ethnicity, and inheritance patterns in the family, and Pedigree analysis.

The concluding chapters 6 and 7 in part 1 is about genetic epidemiology and gene-environment interactions followed by genetic information, ethics, and the law.

The part 2 of the book is a brief on toxicology, teratology, and prenatal diagnosis followed by metabolic disorders and screening in new-borns. Chapter 11 emphasizes paediatric Genetics and health supervision for different genetic disorders such as Down syndrome, fragile X syndrome, etc.

The final chapter of this part is about genetic disorders in adults, genetic counselling, and health behavior. It includes details on cardiovascular diseases, Alzheimer’s disease, cancer, cancer syndromes, and genetic testing.

The final part 3 is focused on health economics, health disparities, and genetic services. It includes the recent hot topics in the field of genomics such as personalized medicine, gene therapy, stem cell research, and many more.

The bioinformatics and genomics are included in the last chapter of the book. This chapter includes details on ethical, legal, and social issues along with professional genetic education and societies, and healthy societies.

Why You Should Buy This Book

  • The book is clearly sectioned into separate parts and separate chapters
  • Individual topics can be easily navigated through in the book
  • Simple, easy, and straightforward writing
  • Recommended for health care studies and genomics-based studies
  • Research resources are also present

Level (best suitable for): Beginner

 

12. Exploring Personal Genomics

Exploring Personal Genomics is a compilation of an inquiry-based approach to understanding the practical medical physiological aspects of personal genomics information.

Broadly the book is classified into two sections. The first section includes our history, previous information, backgrounds, and fundamentals for understanding the biology and molecular mechanism of the human genome. It provides basic data on obtaining an understanding of the digital representation of personal genomic data.

A detailed description of the tools and techniques that could help in understanding personal genomics in a better way is also mentioned. The ancestry, genealogy, and discovery of genetic traits associated with a personal genome can be interpreted.

This study on genomics on a personal level can help in understanding the drug response. Hence, drug response to personal genomics data is written in detail.

Another part of the book is about understanding the design of the techniques that are developed for knowing the interactions between personal genomes and the environment. This section is for advanced readers with the research approach to identify the logic and method behind the development of a technique in personal genomics.

The connection between DNA to physiology and assessing variants and structural variation is also included separately.

Why You Should Buy This Book

  • The book is different and unique since it includes the interesting topic of personal genomic information
  • It is written in simple language and divided into clear sections for easy navigation
  • The book is written for undergraduates and graduates studying in the field of genetics, molecular biology, bioinformatics, and clinical medicine.
  • People belonging to medical fields and professionals working in biomedical science can find interesting research areas through the book
  • Researchers interested in exploring person genetic data will find it relevant and authentic

Level (best suitable for): Advanced

 

13. Precision Medicine: A Guide to Genomics in Clinical Practice

Precision Medicine: A Guide to Genomics in Clinical Practice, is an amazing compilation of information on the advanced application of genomics in clinical practice.

The book is organized very nicely into different parts. It has been broadly divided into three sections. The first section is regarding human planning and pregnancy. It includes a brief description of preconception carrier screening and the stages of pregnancy.

The second section is about childhood. It includes a separate chapter on the new-born. The topics of Emergency medicine and metabolic diseases have been discussed in a separate chapter. The concluding chapter of this section is about childhood and adolescence

The final section is more detailed than the previous two. It is about adulthood and so on. Pharmacogenomics, an emerging science field on understanding the activities of drugs on genomes, is included as a single chapter.

The cardiovascular diseases, cancer predisposition test, and genomic guided cancer treatment decisions are included in the last section. The concluding chapters of the book are about the brain. The last chapter ends with the wellness of human beings.

Why You Should Buy This Book

  • The content of the book is simple with non-technical words
  • Special emphasis on real-life case studies
  • The current and future applications of genomics and precision medicine is discussed in great details
  • The ethical and technical pitfalls have been discussed in brief by the authors
  • Concise organization of the content makes the navigation through the book easier
  • Researchers belonging to the clinical and medical field can find this book valuable

Level (best suitable for): Advanced

 

14. Genome Editing and Engineering

Genome Editing and Engineering is a complete book on genomics that allows editing in genes and manipulations. The book is vast and divided into a total of six sections. The initial pages of the book is an overview of the book design, contents, contributors, and so on.

Part one of the book is a massive collection of various chapters on the biology of endonucleases and regulatory networks. It includes 4 chapters. It includes genome editing techniques in C. elegans, unbiased detection of Off-target cleavage by CRISPR and TALENs, using Integration defective Lentiviral vectors, in Vivo studies of miRNA target interactions using site-specific genome engineering, and employing genome editing to study regulatory RNA interactions.

Part two of the book deals with genome editing in the model organisms. It consists of 6 chapters including topics such as gene editing to create agricultural and biomedical swine models and generation of new model cell lines using ssODN Knockin donors and FACS based Genome editing.

Part three is about technology development and screening. It includes details on CRISPR, genome editing in mice, applications of crisper generation and utilization of CRISPR, and many more.

The fourth section includes details on genome editing in stem cells and regenerative biology. Topics such as therapeutic genome editing in human hematopoietic stem and progenitor cells are written down.

The fifth section is about genome editing in disease biology such as retinal diseases. It includes harnessing the therapeutic potential of long non-coding RNA in immunity as well.

Final section 6 is about the legal and bioethical issues associated with genome editing. It discusses the ethics of human genome editing and regulating ethical concerns through society and policy.

Why You Should Buy This Book

  • A very detailed guide on learning recent genome editing methods and engineering
  • This includes almost every important and relevant topic
  • Real-life examples and case studies are included for a better understanding
  • Recommended for advanced learners belonging to medical and biochemical engineering fields

Level (best suitable for): Advanced

 

15. Data Mining for Genomics and Proteomics

Data Mining for Genomics and Proteomics is a complete package for analyzing gene and protein expression data. The book just includes 6 chapters. Each chapter contains an overview in the beginning and exercises to solve at the end of it.

The first chapter is introductory and hence it includes the basics of proteomics and genomics. The second chapter includes details on the basic methods of analysis of gene expression microarray data.

The third chapter is a brief of biomarker discovery and classification. Biomarkers are an essential part of analysis since they help in the identification of specific compounds.

Chapter 4 is on the informative set of genes, which means that genes that could help in generating some useful data are included here. Chapter 5 is about the brief methods and protocols for the analysis of protein expression data.

Why You Should Buy This Book

  • The book is a step-by-step guide to demonstrate how biomedical studies can lead to discoveries
  • The chapters are small, concise, and straight forward
  • Recommended for students and researchers involved in protein and gene expression data
  • The last and final chapter is about sketches for selected exercises.

Level (best suitable for): Advanced

In this article, we have provided a brief description of the best textbooks on genomics for students belonging to the fields of bioinformatics, computational biology, molecular biology, genomics, genetics, and many more.

The list is an amalgamation for every type of learner belonging to either beginner, intermediate, and advanced level.

We would recommend you to go through the reasons why to buy a particular book. If the reasons interest you in buying that particular book, then go for it. Find more about the authors and their previous work for validating their enormous contribution to these books.

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