17 Best RNA Books To Read in [2022] [UPDATED]

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Every macromolecule that exists in different life forms has a vital role to play. But when we talk about RNA, the discussion becomes way more interesting and amusing. RNA is a dynamic macromolecule with boundless layers of mysteries hidden under its structure.

If you are an intrusive researcher, it is your responsibility to find and unravel every secret that lies unheard-of. To do so, you should read. These are the 17 Best RNA Books that you must read if you want to hit the jackpot with a breakthrough discovery in the RNA world.


Best RNA Books That Must be Read by Every Macromolecular Researcher

Given below is the list and description of 17 most beneficial books on RNA and technologies. However, I would like to recommend some of the highly acclaimed books by the readers across the world.


1. RNA Biology: An Introduction

RNA Biology: An introduction authored by Gunter Meister is a detailed textbook for RNA.

The book is broadly categorized into two sections, one section is about the biology that talks about the Messenger RNA and the coding in RNA, while the second part is about the non-coding regions of RNA, For example, ribosomal RNA, nucleolar RNA, tRNAs, etc.

Every chapter is in detail with an abstract at the start and summary at the end. There is a good set of questions at the chapter end that would clear the concepts in the exam pattern. The key concepts have been elaborated and graphical illustrations are mentioned as per the need.

It includes important topics such as the process of translation, transfer RNA, Ribozymes, RNA’s sensors, regulation of transcription, capping, splicing, export from the nucleus to the cytoplasm, and many more.

Why You Should Buy This Book

  • The book is concisely written in easy language
  • The picture quality is good, necessarily mentioned at every place
  • Recommended to pure biology students and researchers who are interested in RNA molecules study
  • An interesting topic like RNA interference has been included to raise excitement in readers.

Level (best suitable for): Beginner to Intermediate

2. RNA Worlds

RNA Worlds by John F Atkins and two more editors have beautifully presented the story of RNA and its mysteries. Many of the readers think that RNA is just another molecule with some basic properties. However, this book unravels the early evolution and post evolution role and function of RNA.

The initial chapters include the primordial RNA that is, RNA before the DNA existence. This states how RNA was the genetic code as well as the biocatalyst during the early phase. It analyses the role of RNA in the early forms of cells and life.

The next chapters include the evolution of RNA after the development of DNA. It discusses the evolution of ribosomes that RNPs, miRNA, siRNA, non-coding RNA, viral RNA, telomerase RNA, and many more.

You Should Buy This Book

  • For a clear understanding of RNA, both history and present
  • To understand the molecular mechanism and RNA technologies
  • To study enzyme catalysis and storage of information as genetic codes
  • The subtle flow between the chapters in an explanatory way
  • Keep the readers engaged with intriguing stories of evolution

Level (best suitable for): Beginner to Intermediate


3. Molecular Biology of RNA

The molecular biology of RNA is authored by David Elliott and Michael Ladomery. This book is written centrally around RNA and the role it plays in genetics in all the life forms.

RNA is a way more complex and dynamic macromolecule than DNA because of its ability to regulate the gene expression and work as a catalyst in the form of the Ribozyme enzyme.

The authors suggest that RNA would have been an essential component for the existence and origin of life.

Why You Should Buy This Book

  • The text is simple, systematic, and easy to understand
  • This develops the excitement to read about the dynamism of RNA biology
  • It can be helpful in various experiments that could provide pieces of evidence for the underestimated role of RNA
  • Separate boxes with human diseases that occurred due to RNA have been mentioned in every chapter
  • Highly recommended book for studying binding domains, non-coding regions of DNA, and establishing a connection between RNA and its role in epigenetics.
  • This includes modern RNA technology for assessing diseases on a genetic level

Level (best suitable for): Beginner to Intermediate


4. RNA: Life’s Indispensable Molecule

RNA: Life’s indispensable molecule authored by James Darnell, which includes some of the most breakthrough researches on RNA molecules. The author has included his research along with other masterpieces.

It is a systematic flow of text that includes the stepwise deciphering of fundamental questions related to life and the importance of RNA in the origin of life.

The chapter, later on, discuss the mRNA, its generation from proteins, about the non-coding and enzymatic RNAs that play a role in various biochemical processes.

Why You Should Buy This Book

  • Engages the mind of the reader by putting up questions on the existence of life and how RNA plays the role
  • This includes the experiment to answer the questions in a comprehensive way
  • An easy to read and understand textbook with high-resolution pictures wherever needed
  • The book is prescribed for graduates and scientific investigators interested in RNA molecules, for educators and biology historians.

Level (best suitable for): Beginner to Intermediate


5. RNA-seq Data Analysis

RNA-seq Data Analysis by Eija Korpelainen and four more contributors have written this book of practical approach in computational biology. Data analysis has become the most recent method of deciphering important information.

The book lays down the protocol to examine the Differentially Expressed Genes (DEGs) in RNA Seq data and to identify the epigenetic causes for diseases and aberrations.

Every chapter includes a theoretical background and then comes the analysis tool and descriptions of the method along with suitable RNA data examples.

An ideal book to study the state-of-art methods linked with disease diagnosis and then potential drug development.

Why You Should Buy This Book

  • A complete guide for both programming and non-programming scientists
  • It provides the entire analysis workflow in a systematic way
  • The language is easy and detailed for a clear understanding
  • Suitable examples and data is provided to satisfy the approach
  • Research papers from various backgrounds like computer science, molecular biology, structural biology, and genetics has been included in the book, can be read easily

Level (best suitable for): Intermediate to Advance


6. RNA Bioinformatics

RNA Bioinformatics, edited by Ernesto Picardi, is a collection of RNA data analysis techniques. The book provides in-depth RNA bioinformatical methods, and strategies to carefully research the RNA data.

With the development of high-throughput sequencing methodologies, the research of transcriptomes has become convenient as close as up to a single nucleotide.

RNA is not a simple molecule but a complex arrangement of nucleotides. The book includes methods that could predict the secondary and tertiary structure of RNA molecules.

This book includes those computational techniques that could conduct detailed studies on RNA structure and functions.

Why You Should Buy This Book

  • It includes important and relevant topics related to RNA structure folding and sequence
  • It has step by step protocol for bioinformatics analysis
  • It also mentions the materials required and equipment needed to carry out the research
  • The book could help computational biologist and structural molecular scientist to conquer untouched discoveries

Level (best suitable for): Beginner to Intermediate


7. RNA Sequence, Structure, and Function

RNA Sequence, structure, and function edited by Jan Gorodkin and Walter L Ruzzo is the complete book for undergraduate computational biologists and young bioinformaticians.

RNA’s molecules are not just a bunch of nucleotides transcribed from DNA but more than that. The RNA molecules comprise coding and non-coding proteins. Much attention is given to coding regions, but this book pays special attention to the non-coding part of RNA and its role in various cellular processes.

RNA bioinformatics has always created a buzz in the scientific research community. The book includes relevant methodologies and practical computational approaches to learning more about this biologically interesting macromolecule.

Why You Should Buy This Book

  • The book includes the necessary precautions to be taken while performing RNA research on the computer
  • A practical approach towards understanding the dynamic functionalities of an RNA molecule
  • Easy to understand the text and lucid flow of content throughout the chapters
  • It includes topics of successful RNA data researches in recent times.

Level (best suitable for): Intermediate to Advance


8. Handbook of RNA Biochemistry

The handbook of RNA biochemistry edited by a group of four editors is an overview of the chemical nature of the RNA molecule.

The book is segmented into 56 chapters that are divided into four major sections namely- Part 1 RNA Synthesis and Detection, Part 2 Structure Determination, Part 3 RNA Genomics and Bioinformatics, Global approaches, and Part 4 RNA function, RNP Analysis, SELEX, RNAi

The book has received positive responses for its comprehensive style of writing and up-to-date information on hundreds of protocols, experiments, explanations, and expertise hints.

The specialized methods of analysis along with basic and traditional biochemical methods, make the book extraordinary for performing RNA experiments.

Why You Should Buy This Book

  • Written by more than a hundred experts across the world about the biochemical nature of RNAs.
  • It covers all the recent methods for analysis, modification, understanding of the RNAs and the complexes it forms with the proteins
  • It is a quick and reliable reference while performing the practical RNA researches
  • Short, precise, to-the-point information
  • Easy to carry, read, and understand texts
  • Answers all the simple to highly complex question, mentions all the biochemical techniques while the researcher performs experiments with RNA molecules

Level (best suitable for): Beginner to Intermediate


9. Birth of Intelligence: From RNA to Artificial Intelligence

Birth of intelligence: From RNA to artificial intelligence is authored by Daeyeol Lee. The author is aware that the future lies in the hands of machines with smart thinking.

The book is an overview that talks about artificial intelligence. He has described how human intelligence can be evolved and tackled by machines. He explains how artificial intelligence is different from human intelligence and how far can a trained machine be intelligent.

The book elaborates on the biological cause of human intelligence and converting the biological intelligence and behaviours into computational programs.

The author has also proposed that true intelligence is a sign of life form but can be modified into machines with the help of special learning and training.

Why You Should Buy This Book

  • A basic book, easy to understand with simple language
  • Deals with the recent developments of artificial intelligence, learning, and the future it holds
  • The right book to start for machine learning, deep learning, and artificial intelligence

Level (best suitable for): Beginner to Intermediate

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10. RNA Detection and Visualization

RNA’s detection and visualization methods and protocols book is edited by Jeffrey E Gerst. The book is a package of protocols and methodologies to detect RNA molecules in life forms, such as tiny bacteria, to huge mammal cells.

The book is written under the guidance of biomolecular experts. It includes the amalgamation of classics in situ hybridization and advanced live imaging techniques, affinity purification processes, cell fractionation, and computational tools that gives the complete and reliable method to help in research.

A practical researcher with computational knowledge can rely on this book.

It is divided into different chapters that include different relevant topics

Why You Should Buy This Book

  • Chapters include introductions, topics, materials required, and the reagents needed
  • The protocol to be followed in the laboratory and tips and precautions for optimum results are penned down too.
  • Ideal wet laboratory and dry laboratory and manual for RNA based analysis
  • Written in the best possible scientific way
  • Usage of simple language
  • The best protocols for a particular analysis is mentioned

Level (best suitable for): Intermediate to Advance


11. Computational Biology of Non-Coding RNA

Computational biology of non-coding RNA are a collection of RNA analysis protocols edited by Shailendra K Gupta and two more editors.

It consists of recent methods and processes to analyze the non-coding regions of RNA.

This book provides up-to-date advanced processes that lead to the identification of non-coding RNA and the target molecules.

It also leads to the identification of functional annotations and the diseases caused by them.

Why You Should Buy This Book

  • It provides an overview of the workflows associated with non-coding RNA, mostly the discovery of high throughput sequence data, bioinformatics databases, and many more.
  • It provides step by step method, materials, equipment, format, and details on related topics for the readers.
  • It also provides tips and tricks to avoid errors.
  • It’s recommended for medical biology and biotechnology researchers working on RNA and diseases.

Level (best suitable for): Intermediate to Advance


12. Regulating with RNA in Bacteria and Archaea

Regulating with RNA in Bacteria and Archae is a complete volume of fascinating RNA activities inside bacteria and archaea. The book includes the biochemistry and the mechanism of the RNA structures and their effect on physiology.

The function of RNA is not limited to passing the genetic code for coding or playing role in ribosomes, etc. But it has a regulatory role beyond that. With advancements in bioinformatics and structural biology, it became vivid, how they exist in different structures and perform different functions.

Important topics like small RNA, RNA thermometer, riboswitches that regulate core metabolic pathways, iron homeostasis, biofilm formation, and bacterial pathogenesis are included in different chapters.

Why You Should Buy This Book

  • A compilation of the RNA regulation in bacteria by RNA biologists across the world
  • The book is divided into 8 separate sections only related to different types of RNA such as RNases and Helicases, CIS Acting RNAs, CIS Encoded Base pairing RNAs, Trans Encoded Base pairing RNAs, Protein titration and Scaffolding, General Considerations, Emerging topics, Resources.
  • This book clearly states that regulatory RNA is the vital companion that work along with proteins in controlling complex interactions that participate in cellular pathways in low-level organisms.

Level (best suitable for): Intermediate to Advance


13. Single-stranded RNA Phages

Single-stranded RNA phages: From molecular biology to nanotechnology is a collection of comprehensive information on single-stranded RNA phages that were discovered in the early 1960s.

The roles and functionalities of these phages is discussed in detail. How these factors affect the molecular biology, genetic codes, the process of replication, translation, and mutations have been paid attention to.

An interesting part of the book includes the modern applications of phages, their products, and byproducts in different domains of science like vaccinology, evolutionary and environmental studies, biotechnology, nanotechnology, the discovery of genes, etc.

The crucial role of RNA phages and their products in diagnostics can be a revolutionary phase in Medical sciences.

Why You Should Buy This Book

  • A comprehensive and complete guide to understanding the single-stranded RNA phages
  • Summarises the molecular biology of each phage along with the role it plays
  • It shows how the RNA phage products can be applied to nanotechnology and biotechnology
  • It comprises the recent and advanced role of phages in environmental and evolutionary studies.

Level (best suitable for): Beginner to Intermediate


14. RNA-Protein Interaction Protocols

RNA-Protein interaction Protocols: Methods in molecular biology is a fascinating compilation that includes the vital importance of RNA and protein together in cell development.

The entire volume is a step-by-step experimental procedure to study the interactions between the RNA and proteins. It provides the latest and advanced techniques for studying the interactions.

Few sections of the book include the methods to explore, isolate, and characterize RNA protein complexes. The other section includes the analysis and measurement of these interactions. It also mentions related novel techniques and methodologies.

Why You Should Buy This Book

  • The chapter includes a brief introduction, summaries at the end, materials required, reagents needed, step-by-step protocol, precautions, and tips that could be healthy in producing optimum results.
  • An ideal guide for researchers working in the domain of biological interactions.
  • Lab manual for graduate and Ph.D. scholars
  • Written in simple, easy, and understandable language

Level (best suitable for): Intermediate to Advance


15. RNA Interference and CRISPR Technologies

RNA Interference and CRISPR technologies: technical advances and new therapeutic opportunities. This volume is an ideal book to study for advanced learners interested in RNA expression and computational studies.

The main topics included in the book are the roles of RNA interference and CRISPR interferences for inhibiting the expression of genes and their roles in biological functions, chemical modifications, clinical applications, and designs.

The chapters are simple, along with a brief background on the topic. It includes stepwise protocols that focus on the latest technologies related to RNA interference and CRISPR and applications to look at how these methods are unique in their way.

Since it is a laboratory manual, it includes introductions, lists of materials and chemicals required, stepwise protocol precautions, and helpful tips for optimum results.

Why You Should Buy This Book

  • Valuable research manual for students, scientists, graduates, postgraduates, and medical biologists
  • The simple language and understandable text make it highly acclaimed.
  • The book can assist in research and development experiments in the pharmaceutical and biotechnology domains

Level (best suitable for): Intermediate to Advance


16. RNA Methodologies: Laboratory Guide for Isolation and Characterization

RNA Methodologies: Laboratory Guide for Isolation and Characterization is an excellent and complete guide for studying the development of ribonucleic acids over the past decades.

The expert information has been compiled with the help of several scientific writers from across the world.

It includes current, advanced laboratory-tested protocols for the isolation and characterization of both eukaryotic and prokaryotic RNA.

These methods pay special emphasis on transcript profiling along with quantification issues and elaboration of alternative transcription starting sites.

Why You Should Buy This Book

  • The chapters are collectively composed to provide analysis with a clear cut understanding of the research method.
  • To understand RNA and to optimize the time at a working bench, this book could be a great help.
  • There is an enormous number of graphs, tables, and flow charts that could help plan in visualizing and implementing the different phases of your project.
  • The edition also includes the addition of RNA isolation methods such as isolation from tissues, the PCR expansion, and analysis of RNA interference.
  • A chapter is devoted to the molecular biology of plants and an expanded glossary with keywords.

Level (best suitable for): Intermediate to Advance


17. Life from an RNA World: The Ancestor Within

Life from an RNA world: The Ancestor Within, is a biological history and recent developments studied on the dynamic macromolecule RNA.

The author of the book Michael Yarus has splendidly presented the initiation of life on earth from the simple molecule such as RNA, and then how life switches itself towards the complexities on earth.

The book is unusual because the author has used specific words like “Ribocytes” to define RNA cells. He has reviewed the current understanding of life and the history of life.

He has examined the structure of RNA and explains the beginning of the genetic code and how over the years the biological world has metamorphosed.

Why You Should Buy This Book

  • The book leaves readers with scratching heads by the compelling questions put up by the author about the chemical fragility of RNA and the uncertainty at the beginning of the RNA synthetic apparatus.
  • The book provides invaluable insight into early life on earth.
  • It makes us realize about the ancestors within us and accessible to us in the form of RNA.

Level (best suitable for): Beginner to Intermediate

These are some of the Best RNA books available for scientific readers. They are not meant only for the advanced learners but for the readers ranging from Beginner level to Intermediate level.

The list includes some basic books on the primordial RNA, history, and roles. There are some intermediate books for graduates that throws emphasis on catalytic RNAs. The advanced books are the laboratory manuals, which include protocols for RNAi and CRISPR technologies.

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